Journal Article

Three <i>Arabidopsis</i> MBF1 Homologs with Distinct Expression Profiles Play Roles as Transcriptional Co-activators

Kenichi Tsuda, Toshihiro Tsuji, Susumu Hirose and Ken-ichi Yamazaki

in Plant and Cell Physiology

Published on behalf of Japanese Society of Plant Physiologists

Volume 45, issue 2, pages 225-231
Published in print February 2004 | ISSN: 0032-0781
Published online February 2004 | e-ISSN: 1471-9053 | DOI: http://dx.doi.org/10.1093/pcp/pch017
Three Arabidopsis MBF1 Homologs with Distinct Expression Profiles Play Roles as Transcriptional Co-activators

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Multiprotein bridging factor 1 (MBF1) is known to be a transcriptional co-activator that mediates transcriptional activation by bridging between an activator and a TATA-box binding protein (TBP). We demonstrated that expression of every three MBF1 from Arabidopsis partially rescues the yeast mbf1 mutant phenotype, indicating that all of them function as co-activators for GCN4-dependent transcriptional activation. We also report that each of their subtypes shows distinct tissue-specific expression patterns and responses to phytohormones. These observations suggest that even though they share a similar biochemical function, each MBF1 has distinct roles in various tissues and conditions.

Keywords: Keywords: ABA — Arabidopsis thaliana — bZIP — co-activator — MBF1 — transcription.; Abbreviations: 3-AT, 3-aminotriazole; ABRE, ABA-response element; bZIP, basic region/leucine zipper; EMSA, electrophoresis mobility shift assay; GST, glutathione S-transferase; MBF1, multiprotein bridging factor 1; ORF, open reading frame; SA, salicylic acid; TBP, TATA-box binding protein.

Journal Article.  4556 words.  Illustrated.

Subjects: Biochemistry ; Molecular and Cell Biology ; Plant Sciences and Forestry

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