Journal Article

Circadian G<sub>2</sub> Arrest as Related to Circadian Gating of Cell Population Growth in <i>Euglena</i>

Aoen Bolige, Shin-ya Hagiwara, Yulan Zhang and Ken Goto

in Plant and Cell Physiology

Published on behalf of Japanese Society of Plant Physiologists

Volume 46, issue 6, pages 931-936
Published in print June 2005 | ISSN: 0032-0781
Published online June 2005 | e-ISSN: 1471-9053 | DOI: http://dx.doi.org/10.1093/pcp/pci100
Circadian G2 Arrest as Related to Circadian Gating of Cell Population Growth in Euglena

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Cell population growth is gated to occur in particular circadian phases, which has been known for over four decades in various organisms including cyanobacteria and human. However, little is known as to which cell cycle phases from G1 to M are primarily regulated by the circadian rhythm or when in a circadian cycle this primary regulation takes place. We report here that in the flagellate alga Euglena gracilis grown photoautotrophically, the circadian rhythm primarily prevented developmentally matured G2 cells from progressing to mitosis, such that cell population growth occurred only during subjective night. In addition, we found that the circadian rhythm also arrests G1-to-S and S-to-G2 transitions at particular circadian phases.

Keywords: Cell cycle; Circadian rhythms; Euglena gracilis; G2 arrest; Mitosis; CT, circadian time; DD, continuous darkness; FCM, flow cytometry; GT, generation time; LD:1,1, alternation of 1 h light plus 1 h darkness; LL, continuous light; MPF, maturation-promoting factor

Journal Article.  4726 words.  Illustrated.

Subjects: Biochemistry ; Molecular and Cell Biology ; Plant Sciences and Forestry

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