Journal Article

<i>ALBINO AND PALE GREEN 10</i> Encodes BBMII Isomerase Involved in Histidine Biosynthesis in <i>Arabidopsis thaliana</i>

Yoshiteru Noutoshi, Takuya Ito and Kazuo Shinozaki

in Plant and Cell Physiology

Published on behalf of Japanese Society of Plant Physiologists

Volume 46, issue 7, pages 1165-1172
Published in print July 2005 | ISSN: 0032-0781
Published online July 2005 | e-ISSN: 1471-9053 | DOI: http://dx.doi.org/10.1093/pcp/pci119
ALBINO AND PALE GREEN 10 Encodes BBMII Isomerase Involved in Histidine Biosynthesis in Arabidopsis thaliana

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We isolated an Arabidopsis albino and pale green 10 (apg10) mutant which exhibits pale green cotyledons and true leaves at the juvenile stage. We identified a valine to leucine change in BBMII (N′-[(5′-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide) isomerase involved in histidine biosynthesis. The morphological abnormality of apg10 was recovered by histidine supplementation. The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants. We also revealed that the APG10 knockout mutant exhibited embryo lethality, indicating the essential role of the Arabidopsis BBMII isomerase for plant growth.

Keywords: Albino and pale green mutant; Arabidopsis thaliana; BBMII isomerase; Histidine biosynthesis; BAC, bacterial artificial chromosome; BBMII, N′-[(5′-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide; Ds, Dissociation transposon; HDH, histidinol dehydrogenase; HPA, histidinol phosphate aminotransferase; HPP, histidinol phosphate phosphatase; IGPD, imidazoleglycerolphosphate dehydratase; SSLP, single sequence length polymorphism

Journal Article.  5328 words.  Illustrated.

Subjects: Biochemistry ; Molecular and Cell Biology ; Plant Sciences and Forestry

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