Journal Article

Characterization of a Splicing Variant of Plant Aurora Kinase

Daisuke Kurihara, Akira Kawabe, Sachihiro Matsunaga, Katsuyuki Nakagawa, Satoru Fujimoto, Susumu Uchiyama and Kiichi Fukui

in Plant and Cell Physiology

Published on behalf of Japanese Society of Plant Physiologists

Volume 48, issue 2, pages 369-374
Published in print February 2007 | ISSN: 0032-0781
Published online February 2007 | e-ISSN: 1471-9053 | DOI: http://dx.doi.org/10.1093/pcp/pcl064
Characterization of a Splicing Variant of Plant Aurora Kinase

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  • Biochemistry
  • Molecular and Cell Biology
  • Plant Sciences and Forestry

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Aurora kinases play a key role in chromosome segregation and cytokinesis. In plants, three Aurora kinases (AtAUR1–AtAUR3) have been identified in Arabidopsis thaliana. Here, we report an AtAUR2 splicing variant (AtAUR2S), which lacks the fourth exon encoding a part of the kinase domain of AtAUR2. AtAUR2S was shown to have lost its kinase activity to phosphorylate histone H3 at Ser10; however, it maintained its ability to bind to histone H3. The localization pattern of AtAUR2S was the same as that of AtAUR2. The findings suggest that AtAUR2S affects cell division by competing with AtAUR2.

Keywords: Alternative splicing; Arabidopsis thaliana; Aurora kinase; Histone H3

Journal Article.  3495 words.  Illustrated.

Subjects: Biochemistry ; Molecular and Cell Biology ; Plant Sciences and Forestry

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