Journal Article

Circadian Clock Regulates Dynamic Chromatin Modifications Associated with <i>Arabidopsis CCA1</i>/<i>LHY</i> and <i>TOC1</i> Transcriptional Rhythms

Hans Hemmes, Rossana Henriques, In-Cheol Jang, Sanghee Kim and Nam-Hai Chua

in Plant and Cell Physiology

Published on behalf of Japanese Society of Plant Physiologists

Volume 53, issue 12, pages 2016-2029
Published in print December 2012 | ISSN: 0032-0781
Published online November 2012 | e-ISSN: 1471-9053 | DOI: http://dx.doi.org/10.1093/pcp/pcs148
Circadian Clock Regulates Dynamic Chromatin Modifications Associated with Arabidopsis CCA1/LHY and TOC1 Transcriptional Rhythms

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  • Biochemistry
  • Molecular and Cell Biology
  • Plant Sciences and Forestry

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Circadian clocks enable organisms to adapt to a 24 h diurnal cycle and anticipate rhythmic changes in the environment. The Arabidopsis central oscillator contains three genes encoding core clock components. CIRCADIAN CLOCK ASSOCIATED 1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB EXPRESSION 1 (TOC1) reciprocally repress genes encoding each other and are critical for the generation of circadian rhythms controlling many clock outputs. A precise regulation of transcriptional events is, therefore, essential for proper circadian function. Here, we investigated histone 3 (H3) tail modifications of CCA1, LHY and TOC1 under various conditions. We found specific association of only H3K4Me3 and H3K9/14Ac with the translational start site of these three genes. These H3 marks were enriched at circadian time points of their increased transcription at different photoperiods and under free-running conditions, suggesting circadian regulation of H3 modifications. Analysis of clock-compromised CCA1-overexpressing lines provided evidence that light/dark photoperiods signal the establishment of these chromatin changes which are gated by the clock.

Keywords: Arabidopsis thaliana; CCA1; Chromatin modifications; Circadian clock; LHY; TOC1

Journal Article.  7440 words.  Illustrated.

Subjects: Biochemistry ; Molecular and Cell Biology ; Plant Sciences and Forestry

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