Journal Article

Troponin-I, myoglobin, and mass concentration of creatine kinase-MB in acute myocardial infarction

A. Chiu, W.-K. Chan, S.-H. Cheng, C.-K. Leung and C.-H. Choi

in QJM: An International Journal of Medicine

Published on behalf of Association of Physicians of Great Britain and Ireland

Volume 92, issue 12, pages 711-718
Published in print December 1999 | ISSN: 1460-2725
Published online December 1999 | e-ISSN: 1460-2393 | DOI: http://dx.doi.org/10.1093/qjmed/92.12.711
Troponin-I, myoglobin, and mass concentration of creatine kinase-MB in acute myocardial infarction

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Myoglobin, creatine kinase-MB (CKMB) mass concentration and troponin-I are newer biochemical markers for the diagnosis of acute myocardial infarction (AMI). We conducted a prospective study to formulate a model for the collective interpretation of these three markers in the diagnosis of AMI. Eighty-seven patients with AMI had serial serum samples taken to establish the time-frame sensitivity of individual markers. None of the markers had a good sensitivity within the first 4 h of infarction. Myoglobin and CKMB (mass) had sensitivities of 92.3% and 96.2%, respectively, at 4–8 h post infarct. CKMB (mass) and troponin-I had sensitivities >92% at 8–24 h. Troponin-I maintained sensitivity >93% until 72 h. A guideline was formulated based on the results. Our data suggest that troponin-I, myoglobin and CKMB (mass) yield satisfactory diagnostic sensitivity when used with reference to specific time frames. The combined use of these markers can provide valuable information for clinicians in managing AMI patients.

Journal Article.  4906 words.  Illustrated.

Subjects: Medicine and Health

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