Journal Article

Clinical evaluation following the use of mineralized collagen graft for bone defects in revision total hip arthroplasty

Cheng Huang, Liwu Qin, Wei Yan, Xisheng Weng and Xiangjie Huang

in Regenerative Biomaterials

Published on behalf of Chinese Society for Biomaterials

Volume 2, issue 4, pages 245-249
Published in print December 2015 | ISSN: 2056-3418
Published online November 2015 | e-ISSN: 2056-3426 | DOI:

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  • Reproductive Medicine
  • Biological Engineering
  • Materials Science


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Revision total hip arthroplasty (THA) with massive bone loss has been a real challenge for orthopaedic surgeons. Here we describe an approach using mineralized collagen (MC) graft to reconstruct acetabulum and femur with massive bone defects. We identified 89 patients suffering acetabular or femoral bone defects after primary THA, who required revision THA for this study. During the surgery, MC was applied to reconstruct both the acetabular and femoral defects. Harris hip score was used to evaluate hip function while radiographs were taken to estimate bone formation in the defect regions. The average follow-up period was 33.6 ± 2.4 months. None of the components needed re-revised. Mean Harris hip scores were 42.5 ± 3.5 before operation, 75.2 ± 4.0 at 10th month and 95.0 ± 3.6 at the final follow-up. There were no instances of deep infection, severe venous thrombosis or nerve palsy. The present study demonstrated that MC graft can serve as a promising option for revision THA with massive bone deficiency. Meanwhile, extended follow-up is needed to further prove its long-term performance.

Keywords: total hip arthroplasty; revision; bone defect; mineralized collagen; bone substitutes

Journal Article.  2447 words.  Illustrated.

Subjects: Reproductive Medicine ; Biological Engineering ; Materials Science

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