Journal Article

Clinical evaluations of mineralized collagen in the extraction sites preservation

Lu Feng, Liang Zhang, Yun Cui, Tian-Xi Song, Zhi-Ye Qiu, Xiu-Mei Wang and Bao-Sheng Tan

in Regenerative Biomaterials

Published on behalf of Chinese Society for Biomaterials

Volume 3, issue 1, pages 41-48
Published in print March 2016 | ISSN: 2056-3418
Published online January 2016 | e-ISSN: 2056-3426 | DOI:

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  • Reproductive Medicine
  • Biological Engineering
  • Materials Science


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The purpose of this study was to explore the different effects between biomimetic mineralized collagen (MC) and ordinary physically blended hydroxyapatite/collagen (HA/Col) composite in evaluating new bone formation and regenerated bone height in human extraction sockets. Thirty-four patients who cannot retain teeth caused by trauma or decay were randomly selected from Department of Stomatology of Dongzhimen Hospital from December 2013 to December 2014. The patients were randomly divided into two groups. After the operation of tooth extraction, 17 patients were implanted with biomimetic MC (MC group), and other 17 patients were implanted with ordinary physically blended nHA/Col composite (nHA/Col group). X-ray positioning projection by auto-photographing was taken to test the distance between the lowest position and the neighboring CEJm-CEJd immediately, 1 month and 3 months after the operation. The height of new bone formation of the MC group was significantly higher than the nHA/Col group. Biomimetic MC showed better clinical outcomes in the bone formation for extraction site preservation and would have broad application prospect in the field of oral and maxillofacial surgeries.

Keywords: mineralized collagen; biomimetic; extraction site preservation; bone formation height

Journal Article.  4755 words.  Illustrated.

Subjects: Reproductive Medicine ; Biological Engineering ; Materials Science

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