Journal Article

Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

Hon Fai Chan, Siying Ma and Kam W. Leong

in Regenerative Biomaterials

Published on behalf of Chinese Society for Biomaterials

Volume 3, issue 2, pages 87-98
Published in print June 2016 | ISSN: 2056-3418
Published online March 2016 | e-ISSN: 2056-3426 | DOI: http://dx.doi.org/10.1093/rb/rbw009

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Translation of any inventions into products requires manufacturing. Development of drug/gene/cell delivery systems will eventually face manufacturing challenges, which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive cost. Microfluidicu technologies present many advantages to improve the quality of drug/gene/cell delivery systems. They also offer the benefits of automation. What remains unclear is whether they can meet the scale-up requirement. In this perspective, we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems, formation of microscale drug/cell-encapsulated particles, generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/nano-fibers. We also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems.

Keywords: microfluidics; biomanufacturing; nanoparticle; microencapsulation; microfiber

Journal Article.  7675 words.  Illustrated.

Subjects: Reproductive Medicine ; Biological Engineering ; Materials Science

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