Journal Article

Calcium phosphate nanoparticles-based systems for siRNA delivery

Xiaochun Xu, Zehao Li, Xueqin Zhao, Lawrence Keen and Xiangdong Kong

in Regenerative Biomaterials

Published on behalf of Chinese Society for Biomaterials

Volume 3, issue 3, pages 187-195
Published in print September 2016 | ISSN: 2056-3418
Published online March 2016 | e-ISSN: 2056-3426 | DOI: http://dx.doi.org/10.1093/rb/rbw010

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  • Reproductive Medicine
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Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is still a problem due to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium phosphate (CaP) co-precipitate has been used for nearly 40 years for in vitro transfection due to its non-toxic nature and simplicity of preparation. The surface charge of CaP will be tuned into positive by surface modification, which is important for siRNA loading and crossing cell membrane without enzymatic degradation. The new siRNA carrier system will also promote the siRNA escape from lysosome to achieve siRNA sustained delivery and high-efficiency silence. In this review, we focus on the current research activity in the development of CaP nanoparticles for siRNA delivery. These nanoparticles are mainly classified into lipid coated, polymer coated and various other types for discussion.

Keywords: calcium phosphate; siRNA; nanoparticles; delivery

Journal Article.  4796 words.  Illustrated.

Subjects: Reproductive Medicine ; Biological Engineering ; Materials Science

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