Journal Article

Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder

Bruno Wicker, Pierre Fonlupt, Bénédicte Hubert, Carole Tardif, Bruno Gepner and Christine Deruelle

in Social Cognitive and Affective Neuroscience

Volume 3, issue 2, pages 135-143
Published in print June 2008 | ISSN: 1749-5016
Published online March 2008 | e-ISSN: 1749-5024 | DOI: http://dx.doi.org/10.1093/scan/nsn007
Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder

Show Summary Details

Preview

Several recent studies suggest that autism may result from abnormal communication between brain regions. We directly assessed this hypothesis by testing the presence of abnormalities in a model of the functional cerebral network engaged during explicit emotion processing in adults with high functioning autism or Asperger syndrome. Comparison of structural equation models revealed abnormal patterns of effective connectivity, with the prefrontal cortex as a key site of dysfunction. These findings provide evidence that abnormal long-range connectivity between structures of the ‘social brain’ could explain the socio-emotional troubles that characterize the autistic pathology.

Keywords: emotion; autism; prefrontal; effective connectivity; fMRI

Journal Article.  7000 words.  Illustrated.

Subjects: Cognition and Behavioural Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.