Journal Article

Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia

Manuel F. Casanova

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 23, issue 3, pages 517-519
Published in print January 1997 | ISSN: 0586-7614
Published online January 1997 | e-ISSN: 1745-1701 | DOI:
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia

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Neuropathology is a field that correlates autopsy findings to clinical symptomatology. Since the brain has an inordinate number of parceled regions, each having a different function, it makes more sense to work in an inverse fashion and use clinical findings to establish pathological correlations. In this regard, a lesion in the prefrontal lobes can explain some of the salient findings in schizophrenia, for example, scrambled language, disordered thinking, and abnormal behavior. Recent quantitative cytoarchitectural observations by Goldman-Rakic and Selemon sustain such a correlation. By using a computerized image analysis system, these authors have described an abnormally high neuronal density and reduced cortical thickness in many of their patients with schizophrenia. The importance of these findings is discussed in terms of the recent schizophrenia literature.

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Subjects: Child and Adolescent Psychiatry

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