Journal Article

Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis

Joseph Kambeitz, Lana Kambeitz-Ilankovic, Carlos Cabral, Dominic B. Dwyer, Vince D. Calhoun, Martijn P. van den Heuvel, Peter Falkai, Nikolaos Koutsouleris and Berend Malchow

in Schizophrenia Bulletin

Published on behalf of University of Maryland School of Medicine

Volume 42, issue suppl_1, pages S13-S21
Published in print July 2016 | ISSN: 0586-7614
Published online July 2016 | e-ISSN: 1745-1701 | DOI:
Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis

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Findings from multiple lines of research provide evidence of aberrant functional brain connectivity in schizophrenia. By using graph-analytical measures, recent studies indicate that patients with schizophrenia exhibit changes in the organizational principles of whole-brain networks and that these changes relate to cognitive symptoms. However, there has not been a systematic investigation of functional brain network changes in schizophrenia to test the consistency of these changes across multiple studies. A comprehensive literature search was conducted to identify all available functional graph-analytical studies in patients with schizophrenia. Effect size measures were derived from each study and entered in a random-effects meta-analytical model. All models were tested for effects of potential moderator variables as well as for the presence of publication bias. The results of a total of n = 13 functional neuroimaging studies indicated that brain networks in patients with schizophrenia exhibit significant decreases in measures of local organization (g = −0.56, P = .02) and significant decreases in small-worldness (g = −0.65, P = .01) whereas global short communication paths seemed to be preserved (g = 0.26, P = .32). There was no evidence for a publication bias or moderator effects. The present meta- analysis demonstrates significant changes in whole brain network architecture associated with schizophrenia across studies.

Keywords: schizophrenia; connectivity; cognition; graph analysis; meta-analysis

Journal Article.  6218 words.  Illustrated.

Subjects: Child and Adolescent Psychiatry

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