Journal Article

National Toxicology Program Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment

J. R. BUCHER, C. J. PORTIER, J. I. GOODMAN, E. M. FAUSTMAN and G. W. LUCIER

in Toxicological Sciences

Volume 31, issue 1, pages 1-8
Published in print May 1996 | ISSN: 1096-6080
Published online May 1996 | e-ISSN: 1096-0929 | DOI: http://dx.doi.org/10.1093/toxsci/31.1.1
National Toxicology Program Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment

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A workshop entitled “NTP Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment” was held at the 34th Annual Meeting of the Society of Toxicology in Baltimore, Maryland. The purpose of the workshop was to provide an overview of factors currently considered important in the selection of doses for NTP studies, to describe some of the confounding factors that can result from the indiscriminate use of bioassay data in quantitative risk assessment, and to suggest ways in which information from mechanistic studies or studies of biomarkers of exposure or effect might be used to better advantage in risk assessment.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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