Journal Article

Health Effects of Subchronic Exposure to Low Levels of Wood Smoke in Rats

Yohannes Tesfaigzi, Shashibhushan P. Singh, Jennifer E. Foster, Justin Kubatko, Edward B. Barr, Philip M. Fine, Jacob D. McDonald, Fletcher F. Hahn and Joe L. Mauderly

in Toxicological Sciences

Volume 65, issue 1, pages 115-125
Published in print January 2002 | ISSN: 1096-6080
Published online January 2002 | e-ISSN: 1096-0929 | DOI:
Health Effects of Subchronic Exposure to Low Levels of Wood Smoke in Rats

More Like This

Show all results sharing these subjects:

  • Medical Toxicology
  • Toxicology (Non-medical)


Show Summary Details


Wood smoke is a significant source of air pollution in many parts of the United States, and epidemiological data suggest a causal relationship between elevated wood smoke levels and health effects. The present study was designed to provide information on the potential respiratory health responses to subchronic wood smoke exposures in a Native American community in New Mexico. Therefore, this study used the same type of wood under similar burning conditions and wood smoke particle concentrations to mimic the conditions observed in this community. Brown Norway rats were exposed 3 h/day, 5 days/week for 4 or 12 weeks to air as control, or to 1 or 10 mg/m3 concentrations of wood smoke particles from pinus edulis. The wood smoke consisted of fine particles (< 1 μm) that formed larger chains and aggregates having a size distribution of 63–74% in the < 1-μm fraction and 26–37% in the > 1-μm fraction. The particle-bound material was primarily composed of carbon, and the majority of identified organic compounds consisted of sugar and lignin derivatives. Pulmonary function, specifically carbon monoxide-diffusing capacity and pulmonary resistance, was somewhat affected in the high-exposure group. Mild chronic inflammation and squamous metaplasia were observed in the larynx of the exposed groups. The severity of alveolar macrophage hyperplasia and pigmentation increased with smoke concentration and length of exposure, and the alveolar septae were slightly thickened. The content of mucous cells lining the airways changed from Periodic Acid Schiff- to Alcian Blue-positive material in the low-exposure group after 90 days. Together, these observations suggest that exposure to wood smoke caused minor but significant changes in Brown Norway rats. Further studies are needed to establish whether exposure to wood smoke exacerbates asthmalike symptoms that resemble those described for children living in homes using wood stoves for heating and cooking.

Keywords: wood smoke; particles; chemical composition; rat; pulmonary function; histopathology; cytokines; lymphocytes

Journal Article.  7724 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.