Journal Article

Associations between Weight Loss-Induced Changes in Plasma Organochlorine Concentrations, Serum T<sub>3</sub> Concentration, and Resting Metabolic Rate

Catherine Pelletier, Eric Doucet, Pascal Imbeault and Angelo Tremblay

in Toxicological Sciences

Volume 67, issue 1, pages 46-51
Published in print May 2002 | ISSN: 1096-6080
Published online May 2002 | e-ISSN: 1096-0929 | DOI: http://dx.doi.org/10.1093/toxsci/67.1.46
Associations between Weight Loss-Induced Changes in Plasma Organochlorine Concentrations, Serum T3 Concentration, and Resting Metabolic Rate

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Organochlorine compounds are released from body fat into the bloodstream during weight loss. Because these compounds may impair thyroid status, which is implicated in the control of resting metabolic rate (RMR), the aim of this study was to determine if the augmentation in plasma organochlorine concentrations might be associated with the decrease in serum T3 concentration and RMR observed in response to body weight loss. Plasma organochlorine concentrations, serum T3 concentration, and RMR were measured before and after weight loss in 16 obese men who followed a nonmacronutrient-specific energy-restricted diet for 15 weeks. As expected, a significant decrease in serum T3 concentration and RMR was observed after the program, whereas concentrations of most detected organochlorines were significantly increased. Changes in organochlorine concentrations were negatively associated with changes in serum T3 concentration (significantly for p,p`-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and PCB 170) and with changes in RMR adjusted for weight loss (significantly for HCB and PCB 156). In conclusion, organochlorines released in plasma during weight loss are associated with the documented decrease in serum T3 concentration and RMR. Further studies are needed to verify whether these findings are causally related.

Keywords: obesity; weight loss; organochlorines; PCB; thyroid hormones; energy expenditure

Journal Article.  4932 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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