Journal Article

Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes

André Picard, Golbahar Palavan, Stéphanie Robert, Danielle Pesando and Brigitte Ciapa

in Toxicological Sciences

Volume 73, issue 1, pages 141-148
Published in print May 2003 | ISSN: 1096-6080
Published online May 2003 | e-ISSN: 1096-0929 | DOI: http://dx.doi.org/10.1093/toxsci/kfg043
Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes

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Methoxychlor, lindane, and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.

Keywords: pesticide; methoxychlor; dieldrin; lindane; starfish; mouse; maturation; fertilization; meiosis

Journal Article.  6096 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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