Journal Article

The Mitochondrial Benzodiazepine Receptor as a Potential Target Protein for Drug Development: Demonstration of Functional Significance with Cell Lines Exhibiting Differential Expression of Bcl-2

Lawrence H. Lash

in Toxicological Sciences

Volume 74, issue 1, pages 1-3
Published in print July 2003 | ISSN: 1096-6080
Published online July 2003 | e-ISSN: 1096-0929 | DOI: http://dx.doi.org/10.1093/toxsci/kfg140
The Mitochondrial Benzodiazepine Receptor as a Potential Target Protein for Drug Development: Demonstration of Functional Significance with Cell Lines Exhibiting Differential Expression of Bcl-2

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The article highlighted in this issue is “Reversal of Bcl-2 Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor” by Donna E. Muscarella, Kerry A. O’Brien, Ann T. Lemley, and Stephen E. Bloom from Cornell University in Ithaca, NY (pp. 66–73). The following brief review summarizes their findings, highlights the novel biological model and experimental approach used, and explores potential mechanistic and therapeutic implications of these findings.

Journal Article.  1677 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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