Journal Article

Heterogeneity of Toxicant Response: Sources of Human Variability

Justin E. Aldridge, Jennifer A. Gibbons, Meghan M. Flaherty, Marisa L. Kreider, Jocelyn A. Romano and Edward D. Levin

in Toxicological Sciences

Volume 76, issue 1, pages 3-20
Published in print November 2003 | ISSN: 1096-6080
Published online November 2003 | e-ISSN: 1096-0929 | DOI: https://dx.doi.org/10.1093/toxsci/kfg204
Heterogeneity of Toxicant Response: Sources of Human Variability

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While risk assessment models attempt to predict human risk to toxicant exposure, in many cases these models cannot account for the wide variety of human responses. This review addresses several primary sources of heterogeneity that may affect individual responses to drug or toxicant exposure. Consideration was given to genetic polymorphisms, age-related factors during development and senescence, gender differences associated with hormonal function, and preexisting diseases influenced by toxicant exposure. These selected examples demonstrate the need for additional steps in risk assessment that are needed to more accurately predict human responses to toxicants and drugs.

Journal Article.  15284 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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