Journal Article

Diesel Exhaust Particles in the Lung Aggravate Experimental Acute Renal Failure

Abderrahim Nemmar, Suhail Al-Salam, Shaheen Zia, Javed Yasin, Isehaq Al Husseni and Badreldin H. Ali

in Toxicological Sciences

Volume 113, issue 1, pages 267-277
Published in print January 2010 | ISSN: 1096-6080
Published online October 2009 | e-ISSN: 1096-0929 | DOI:
Diesel Exhaust Particles in the Lung Aggravate Experimental Acute Renal Failure

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Inhaled particles are associated with pulmonary and extrapulmonary effects. Also, acute renal failure (ARF) is associated with increased mortality, related to pulmonary complications. Here, we tested the possible potentiating effect of diesel exhaust particles (DEP) in an animal model of ARF induced by a single ip injection of cisplatin (CP, 6 mg/kg) in rats. Six days later, the rats were intratracheally instilled with either DEP (0.5 or 1 mg/kg) or saline (control) and renal, systemic, and pulmonary variables were studied 24 h thereafter. CP increased the serum concentrations of urea and creatinine and reduced glutathione (GSH) concentration and superoxide dismutase activity in renal cortex. CP caused renal tubular necrosis; increased urine volume, protein concentrations, and N-acetyl-β-D-glucosaminidase (NAG) activity; and decreased urine osmolality. The combination of DEP and CP aggravated the CP-induced effects on serum urea and creatinine, urine NAG activity, and renal GSH. The arterial O2 saturation and PO2 were significantly decreased in CP + DEP versus CP + saline and CP + DEP versus DEP. The number of platelets was reduced in DEP compared to saline-treated rats and CP + DEP versus DEP alone or CP + saline. Increases in macrophage and neutrophils numbers in bronchoalveolar lavage were found in DEP versus saline group and CP + DEP versus CP. Histopathological changes in lungs of DEP-treated rats were aggravated by the combination of CP + DEP. These included marked interstitial cell infiltration and congestion. We conclude that the presence of DEP in the lung aggravated the renal, pulmonary, and systemic effects of CP-induced ARF.

Keywords: air pollution; diesel exhaust particles; lung inflammation; acute renal failure

Journal Article.  6549 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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