Journal Article

Arsenolysis and Thiol-Dependent Arsenate Reduction

David J. Thomas

in Toxicological Sciences

Volume 117, issue 2, pages 249-252
Published in print October 2010 | ISSN: 1096-6080
Published online July 2010 | e-ISSN: 1096-0929 | DOI:
Arsenolysis and Thiol-Dependent Arsenate Reduction

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Conversion of arsenate to arsenite is a critical event in the pathway that leads from inorganic arsenic to a variety of methylated metabolites. The formation of methylated metabolites influences distribution and retention of arsenic and affects the reactivity and toxicity of these intermediates. Indeed, some of the toxic and carcinogenic effects associated with exposure to arsenate or arsenite are probably mediated by methylated arsenicals. Recent work has demonstrated a biologically plausible role for phosphorolytic-arsenolytic enzymes in a reaction scheme in which an “activated” arsenate ester is readily reduced by thiols to arsenite. Thiol-dependent reduction of arsenate esters formed by arsenolysis may be one of several functionally reductant processes that control the flux of arsenic into the cellular pathway for arsenic methylation. Integrating these reductive processes into a conceptual model for arsenic metabolism may provide new insights into the cellular machinery for handling this toxic metalloid.

Keywords: arsenate; arsenolysis; thiols; glutathione; arsenate esters

Journal Article.  1790 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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