Journal Article

Evaluation of Iodide Deficiency in the Lactating Rat and Pup Using a Biologically Based Dose-Response Model*

Jeffrey W. Fisher, Shuang Li, Kevin Crofton, R. Thomas Zoeller, Eva D. McLanahan, Annie Lumen and Mary E. Gilbert

in Toxicological Sciences

Volume 132, issue 1, pages 75-86
Published in print March 2013 | ISSN: 1096-6080
Published online January 2013 | e-ISSN: 1096-0929 | DOI: https://dx.doi.org/10.1093/toxsci/kfs336
Evaluation of Iodide Deficiency in the Lactating Rat and Pup Using a Biologically Based Dose-Response Model*

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A biologically based dose-response (BBDR) model for the hypothalamic-pituitary thyroid (HPT) axis in the lactating rat and nursing pup was developed to describe the perturbations caused by iodide deficiency on the HPT axis. Model calibrations, carried out by adjusting key model parameters, were used as a technique to evaluate HPT axis adaptations to dietary iodide intake in euthyroid (4.1–39 µg iodide/day) and iodide-deficient (0.31 and 1.2 µg iodide/day) conditions. Iodide-deficient conditions in both the dam and the pup were described with increased blood flow to the thyroid gland, TSH-mediated increase in thyroidal uptake of iodide and binding of iodide in the thyroid gland (organification), and, in general, reduced thyroid hormone production and metabolism. Alterations in thyroxine (T4) homeostasis were more apparent than for triiodothyronine (T3). Model-predicted average daily area-under-the-serum-concentration-curve (nM-day) values for T4 at steady state in the dam and pup decreased by 14–15% for the 1.2 µg iodide/day iodide-deficient diet and 42–52% for the 0.31 µg iodide/day iodide-deficient diet. In rat pups that were iodide deficient during gestation and lactation, these decreases in serum T4 levels were associated with declines in thyroid hormone in the fetal brain and a suppression of synaptic responses in the hippocampal region of the brain of the adult offspring (Gilbert et al. , 2013).

Keywords: BBDR; HPT axis; lactation; rat; iodide deficiency; thyroid hormones.

Journal Article.  9000 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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