Journal Article

Food Emulsifier Polysorbate 80 Increases Intestinal Absorption of Di-(2-Ethylhexyl) Phthalate in Rats

Yu Lu, Ying-Ying Wang, Nan Yang, Dan Zhang, Feng-Yi Zhang, Hai-Tao Gao, Wen-Ting Rong, Shu-Qin Yu and Qian Xu

in Toxicological Sciences

Volume 139, issue 2, pages 317-327
Published in print June 2014 | ISSN: 1096-6080
Published online March 2014 | e-ISSN: 1096-0929 | DOI: http://dx.doi.org/10.1093/toxsci/kfu055
Food Emulsifier Polysorbate 80 Increases Intestinal Absorption of Di-(2-Ethylhexyl) Phthalate in Rats

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The aim of the present research was to explore whether food emulsifier polysorbate 80 can enhance the absorption of di-(2-ethylhexyl) phthalate (DEHP) and its possible mechanism. We established the high-performance liquid chromatography (HPLC) method for detecting DEHP and its major metabolite, mono-ethylhexyl phthalate (MEHP) in rat plasma, and then examined the toxicokinetic and bioavailability of DEHP with or without polysorbate 80 in rats. The study of its mechanism to increase the absorption of phthalates demonstrated that polysorbate 80 can induce mitochondrial dysfunction in time- and concentration-dependence manners in Caco-2 cells by reducing mitochondrial membrane potential, diminishing the production of the adenosine triphosphate, and decreasing the activity of electron transport chain. Our results indicated that food emulsifier applied in relatively high concentrations in even the most frequently consumed foods can increase the absorption of DEHP, and its role may be related to the structure and function damages of mitochondria in enterocytes.

Keywords: DEHP; food emulsifier; polysorbate 80; toxicokinetic; absorption; P-glycoprotein; mitochondria

Journal Article.  6706 words.  Illustrated.

Subjects: Medical Toxicology ; Food Microbiology

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