Journal Article

Blood Sugar and Serum Insulin Response in Protein-energy Malnutrition

B. K. Das, Ramesh Jayanthy, J. K. Agarwal, O. P. Mishra and R. P. Bhatt

in Journal of Tropical Pediatrics

Volume 44, issue 3, pages 139-141
Published in print June 1998 | ISSN: 0142-6338
Published online June 1998 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/44.3.139
Blood Sugar and Serum Insulin Response in Protein-energy Malnutrition

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Blood sugar and serum insulin levels in the fasting state and following an oral glucose load in children with protein-energy malnutrition (PEM) were studied. Twenty-nine children with PEM (15 marasmus, 7 kwashiorkor, and 7 marasmic kwashiorkor) and eight healthy children aged between 6 and 60 months were the subjects of the study. Fasting samples were collected after a 6 h fast. Postglucose samples were collected after an oral glucose load of 1.75 g/kg. Serum insulin was estimated by radioimmunoassay and glucose by the glucose oxidase method. In malnourished children, the mean fasting blood glucose levels were significantly lower. Two hours following an oral glucose load, only marasmus and marasmic kwashiorkor patients showed significantly higher blood glucose levels. Similarly, the fasting serum insulin levels were significantly lower in malnourished children. Two hours after the oral glucose load, serum insulin levels increased significantly in malnourished children but fell well short of the control values. The insulin:glucose ratio was consistently low in all cases but was more marked in PEM patients, both in the basal state as well as after oral glucose loading.

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Subjects: Paediatrics ; Antitrust Issues and Policies

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