Journal Article

Congenital Chloride Diarrhoea in Kuwait: A Clinical Reappraisal

Mona H. Badawi, M. Zaki, E.A.R. Ismail and A. Majid Molla

in Journal of Tropical Pediatrics

Volume 44, issue 5, pages 296-299
Published in print October 1998 | ISSN: 0142-6338
Published online October 1998 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/44.5.296
Congenital Chloride Diarrhoea in Kuwait: A Clinical Reappraisal

More Like This

Show all results sharing these subjects:

  • Paediatrics
  • Antitrust Issues and Policies

GO

Show Summary Details

Preview

Congenital chloride diarrhoea (CCD) is a recessively inherited disorder of chloride transport in the distal ileum and colon. Congenital chloride diarrhoea is a common metabolic disorder in Kuwait with an incidence of 1/3200. Clinical findings in 14 children with CCD are reported over a period of 4 years. Maternal polyhydramnios, abdominal distension, watery diarrhoea, and a high faecal chloride level > 90 mmol/1 were the cardinal features in the neonatal period. In spite of the classical features ofthis disease 75 per cent of our cases were diagnosed beyond the neonatal period and all demonstratedchronic diarrhoea and failure to thrive, with hypochloraemia, hypokalaemia, and metabolic alkalosis. The practice of ultrasonic examination for pregnant women with polyhydramnios and, particularly, for those with previously affected siblings led to early identification of new cases among our population recently. The antenatal ultrasonic examination showed dilated intestinal loops which suggest CCD. The diagnosis was confirmed by a high faecal chloride level.

Journal Article.  0 words. 

Subjects: Paediatrics ; Antitrust Issues and Policies

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.