Journal Article

Oxidative Stress is Not Enhanced in Non‐malnourished Infants with Persistent Diarrhea

E. Granot, M. Binsztok, D. Fraser, R. J. Deckelbaum and Z. Weizman

in Journal of Tropical Pediatrics

Volume 47, issue 5, pages 284-287
Published in print October 2001 | ISSN: 0142-6338
Published online October 2001 | e-ISSN: 1465-3664 | DOI:
Oxidative Stress is Not Enhanced in Non‐malnourished Infants with Persistent Diarrhea

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Increased concentrations of reactive oxygen species (ROS) and depleted antioxidant defences have been implicated in a cycle of infection, malabsorption and malnutrition, leading to persistent diarrhea. In order to determine whether in non‐malnourished children oxidative stress predisposes to the development of persistent diarrhea, infants with acute diarrhea (< 7 days) (n = 39) were compared to infants with persistent diarrhea (> 14 days) (n = 38). Lipid peroxidation was assessed by the TBARs assay and expressed as malondialdehyde equivalent content (nmol MDA/ml plasma), and levels of plasma antioxidants vitamin A and vitamin E were determined. In infants with acute and persistent diarrhea nutritional status, as assessed by weight/height and height‐for‐age, hemoglobin levels, serum albumin and immunoglobulin levels, did not differ between groups. Serum vitamin A and vitamin E levels did not differ in infants with acute or persistent diarrhea. TBARs, expressed as nmol MDA/ml plasma did not differ between infants with acute or persistent diarrhea and furthermore did not differ from levels in a healthy, similar age, control group. Non‐malnourished infants with persistent diarrhea do not exhibit plasma antioxidant depletion or enhanced lipid peroxidation. In these infants, oxidative stress, as reflected in plasma, does not play a role in the pathogenesis of persistent diarrhea.

Journal Article.  0 words. 

Subjects: Paediatrics

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