Journal Article

Eradication of <i>Cryptosporidium</i> in Four Children with Acute Lymphoblastic Leukemia

Omar Trad, Pauline Jumaa, Sayenna Uduman and Akhtar Nawaz

in Journal of Tropical Pediatrics

Volume 49, issue 2, pages 128-130
Published in print April 2003 | ISSN: 0142-6338
Published online April 2003 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/49.2.128
Eradication of Cryptosporidium in Four Children with Acute Lymphoblastic Leukemia

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Four children on chemotherapy for acute lymphoblastic leukemia presented with severe diarrhea and dehydration. Cryptosporidium was identified in the stools using modified Ziehl–Neelsen stain. Two of them received paromomycin and responded well. One was started on paromomycin for 10 days and although there was clinical improvement, his stools examination continued to be positive for Cryptosporidium. He then received azithromycin for 10 days. He responded well and his stools became negative for Cryptosporidium. The fourth patient received azithromycin from the start and responded well. Cryptosporidium should be considered in all immunocompromised children with severe or prolonged diarrhea, and since it is not seen in a routine ova and parasite examination, the laboratory should be notified for diagnostic confirmation using modified Ziehl–Neelsen stain. Immunocompromised children with Cryptosporidium diarrhea may benefit from paromomycin or azithromycin therapy.

Journal Article.  0 words. 

Subjects: Paediatrics

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