Journal Article

Passive Immunity to Measles in the Breastmilk and Cord Blood of Some Nigerian Subjects

O. Oluseyi Oyedele, S. O. Odemuyiwa, W. Ammerlaan, C. P. Muller and F. D. Adu

in Journal of Tropical Pediatrics

Volume 51, issue 1, pages 45-48
Published in print February 2005 | ISSN: 0142-6338
Published online February 2005 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmh073
Passive Immunity to Measles in the Breastmilk and Cord Blood of Some Nigerian Subjects

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Maternal and cord blood collected from 33 Nigerian mother–child pairs were tested for measlessepcific IgG. All 33 had protective measles antibodies at the time of delivery with a positive correlation of r = 0.87. Determination of the rate of waning of these antibodies revealed that 58 per cent of these children had lost the protective maternal antibody by the age of 4 months and only 3 per cent of the children had enough antibody to protect them between the ages of 6–9 months. Fifty-five colostrum samples from the same mothers and 347 breastmilk samples collected at various periods of breastfeeding also showed that anti-measles IgA had dropped below the protective cut-off within the first 2 weeks of birth. It is evident that the Nigerian child is born with solid anti-measles antibody but the rate of waning has left a large number unprotected before the first dose of the vaccine. There is an urgent need to review the measles vaccination programme in Nigeria to protect these susceptible infants.

Journal Article.  0 words. 

Subjects: Paediatrics

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