Journal Article

Resetting the Detection Level of Cord Blood Thyroid Stimulating Hormone (TSH) for the Diagnosis of Congenital Hypothyroidism

O. O. Ogunkeye, A. I. Roluga and F. A. Khan

in Journal of Tropical Pediatrics

Volume 54, issue 1, pages 74-77
Published in print February 2008 | ISSN: 0142-6338
Published online September 2007 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmm082
Resetting the Detection Level of Cord Blood Thyroid Stimulating Hormone (TSH) for the Diagnosis of Congenital Hypothyroidism

Show Summary Details

Preview

An appraisal of a 17-year primary thyroid stimulating hormone (TSH) screening programme for the detection of congenital hypothyroidism was carried out to establish the reference interval of cord blood TSH in unaffected infants; the mean cord blood TSH concentration of affected infants and the incidence of congenital hypothyroidism in the Najran province of Saudi Arabia. Our findings show a reference interval of cord blood TSH of 2.0–16.8 mU/l in unaffected infants; a mean cord blood TSH concentration of 399 mU/l in affected infants; a false positive rate for the diagnosis of at-risk infants of 1.02% and a congenital hypothyroidism incidence rate of 34/100 000 (1 : 2931) live births. These findings suggest that there is a need to reset the cord blood TSH concentration for the detection of at-risk infants. We suggest that the detection level of cord blood TSH for the recognition of at-risk infants can be set at 90 mU/l rather than the recommended level of 30 mU/l. This should reduce the false positive rate for detection of infants at risk of congenital hypothyroidism.

Journal Article.  1897 words.  Illustrated.

Subjects: Paediatrics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.