Journal Article

Pneumococcal Meningitis in Taiwanese Children: Emphasis on Clinical Outcomes and Prognostic Factors

Ming-Han Tsai, Shih-Hsiang Chen, Chih-Yi Hsu, Dah-Chin Yan, Meng-Hsiu Yen, Cheng-Hsun Chiu, Yhu-Chering Huang and Tzou-Yien Lin

in Journal of Tropical Pediatrics

Volume 54, issue 6, pages 390-394
Published in print December 2008 | ISSN: 0142-6338
Published online August 2008 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmn046
Pneumococcal Meningitis in Taiwanese Children: Emphasis on Clinical Outcomes and Prognostic Factors

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Pneumococcal meningitis causes high morbidity or mortality in childhood despite the progress in medicine. Children with pneumococcal meningitis were identified and retrospectively reviewed. Forty-nine children were eligible, with mortality in 24.5% of all and neurological sequelae in 40.5% of survivors. In the analysis of clinical profiles, ventilator support (p = 0.001), septic shock (p < 0.001), multiple organ failure (p < 0.001) and lower cerebrospinal fluid (CSF) leukocyte count (p = 0.001) were more frequently found in non-survivors. Besides, CSF protein (p = 0.006) was higher in survivors with neurological sequelae. Initial dexamethasone usage and disease severity did not affect the occurrence of neurological sequelae. Multivariate logistic regression analysis revealed that CSF leukocyte count 200 mm3 (p = 0.013) and protein level 330 g l−1 (p = 0.022) were significantly risk factors associated with poor outcomes, and physicians should be cautious if such conditions occur.

Keywords: meningitis; Streptococcus pneumoniae; children; outcomes

Journal Article.  2129 words. 

Subjects: Paediatrics

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