Journal Article

Development of Dual-class Antiretroviral Drug Resistance in a Child Coinfected with HIV and Tuberculosis: A Case Report from KwaZulu-Natal, South Africa

Richard A. Murphy, Holly France, Henry Sunpath, Michelle L. Gordon, Vincent C. Marconi, Daniel R. Kuritzkes and Kenneth McIntosh

in Journal of Tropical Pediatrics

Volume 55, issue 1, pages 60-62
Published in print February 2009 | ISSN: 0142-6338
Published online September 2008 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmn074
Development of Dual-class Antiretroviral Drug Resistance in a Child Coinfected with HIV and Tuberculosis: A Case Report from KwaZulu-Natal, South Africa

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The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug–drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.

Journal Article.  1440 words. 

Subjects: Paediatrics

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