Journal Article

Role of Astrovirus in Intussusception in Nigerian infants

M. Aminu, E. A. Ameh, A. Geyer, M. D. Esona, M. B. Taylor and A. D. Steele

in Journal of Tropical Pediatrics

Volume 55, issue 3, pages 192-194
Published in print June 2009 | ISSN: 0142-6338
Published online December 2008 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmn101
Role of Astrovirus in Intussusception in Nigerian infants

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Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein–Barr virus are reported in 20–50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription–polymerase chain reaction (RT–PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.

Keywords: intussusception; infants; astroviruses

Journal Article.  774 words. 

Subjects: Paediatrics

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