Journal Article

Rotavirus Infections among HIV-Infected Children in Nairobi, Kenya

Nicholas M. Kiulia, Julia K. Nyaundi, Ina Peenze, Atunga Nyachieo, Rachel N. Musoke, Andrew D. Steele and Jason M. Mwenda

in Journal of Tropical Pediatrics

Volume 55, issue 5, pages 318-323
Published in print October 2009 | ISSN: 0142-6338
Published online March 2009 | e-ISSN: 1465-3664 | DOI:
Rotavirus Infections among HIV-Infected Children in Nairobi, Kenya

Show Summary Details


Human rotaviruses have emerged as a leading cause of acute diarrhea in children <5 years of age worldwide. Although there are previous reports relating to various aspects of rotaviruses, there is limited data on the involvement of rotavirus infection in HIV-infected children. We therefore evaluated the importance of rotavirus infections in HIV-related diarrhea in Kenyan children. Fecal samples were collected from a total of 207 children during the period February 1999 to June 2000 and screened for HRV antigen by enzyme-linked immunosorbent assay (ELISA). Positive samples were analyzed by VP6 subgroup specificity assay, by polyacrylamide gel electrophoresis (PAGE) and reverse transcriptase/polymerase chain reaction (RT–PCR). Fourteen percent (29/207) of the samples were positive. HIV-seropositive children with diarrhea were more likely than their counterparts without diarrhea to have rotaviruses [23.3% (10/43) versus 2.9% (2/70); p = 0.0001]. Rotavirus strain G3P[6] was predominant. These results indicate that rotavirus is an important viral etiological agent causing diarrhea in HIV-seropositive children.

Keywords: rotavirus; HIV; genotypes; vaccine

Journal Article.  3029 words. 

Subjects: Paediatrics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.