Journal Article

Serum Levels of Ghrelin, Tumor Necrosis Factor-α and Interleukin-6 in Infants and Children with Congenital Heart Disease

Mohamed Farouk Afify, Gamal B. Mohamed, Mohamed Abd El-Maboud and Esmat A. Abdel-Latif

in Journal of Tropical Pediatrics

Volume 55, issue 6, pages 388-392
Published in print December 2009 | ISSN: 0142-6338
Published online June 2009 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmp036
Serum Levels of Ghrelin, Tumor Necrosis Factor-α and Interleukin-6 in Infants and Children with Congenital Heart Disease

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Objective: To estimate serum levels of ghrelin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in infants and children with congenital heart disease (CHD), compared with levels in age-matched controls, and to correlate the levels of ghrelin with TNF-α and IL-6.

Design: Case–control study.

Setting: Suzan Moubarak Hospital of Al-Minya University, Egypt.

Patients: We measured serum ghrelin, TNF-α and IL-6 levels using ELISA in 60 patients with CHD (40 acyanotic and 20 cyanotic) and in 20 control subjects.

Results: Our results showed that patients with CHD, regardless of the presence or absence of cyanosis, had significantly higher serum ghrelin, TNF-α and IL-6 than controls (p = 0.000). Serum levels of ghrelin and TNF-α in the acyanotic patients were significantly higher than in the cyanotic patients (p = 0.000). On the other hand, there was no significant difference in serum levels of IL-6 between the acyanotic and the cyanotic patients (p = 0.126). In acyanotic and cyanotic patients with CHD, there was a positive correlation between ghrelin and TNF-α (r = 0.424; p = 0.006 and r = 0.577; p = 0.008, respectively). Ghrelin levels were not correlated to IL-6 in the acyanotic and cyanotic patients with CHD (r = −0.211; p = 0.216 and r = −0.341; p = 0.08, respectively).

Conclusion: Serum ghrelin, TNF-α and IL-6 levels are elevated in patients with CHD whether acyanotic or cyanotic. Increased ghrelin levels represent malnutrition and growth retardation in these patients. The relation of ghrelin with TNF-α may be explained by the possible effect of chronic congestive heart failure and chronic shunt hypoxemia.

Keywords: ghrelin; cytokines; children; congenital heart disease

Journal Article.  1994 words.  Illustrated.

Subjects: Paediatrics

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