Journal Article

Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda

Laurence Ahoua, Harriet Ayikoru, Katherine Gnauck, Grace Odaru, Emmanuel Odar, Christine Ondoa–Onama, Loretxu Pinoges, Suna Balkan, David Olson and Mar Pujades-Rodríguez

in Journal of Tropical Pediatrics

Volume 56, issue 1, pages 43-52
Published in print February 2010 | ISSN: 0142-6338
Published online July 2009 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmp054
Evaluation of a 5-year Programme to Prevent Mother-to-child Transmission of HIV Infection in Northern Uganda

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Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19 017 women, 1 037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother–infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07–3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42–4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16–0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.

Journal Article.  4742 words.  Illustrated.

Subjects: Paediatrics

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