Journal Article

Risk Factors for Extended-Spectrum β-Lactamase Producing <i>Escherichia Coli</i> and <i>Klebsiella Pneumoniae</i> Acquisition in a Neonatal Intensive Care Unit

S. Shakil, S. Z. Ali, M. Akram, S. M. Ali and A. U. Khan

in Journal of Tropical Pediatrics

Volume 56, issue 2, pages 90-96
Published in print April 2010 | ISSN: 0142-6338
Published online July 2009 | e-ISSN: 1465-3664 | DOI:
Risk Factors for Extended-Spectrum β-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Acquisition in a Neonatal Intensive Care Unit

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This study was made to find the prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichea coli and Klebsiella pneumoniae in neonatal intensive care unit (NICU) and to identify the risk factors associated with the acquisition of these organisms. Risk factors associated with ESBL-producing E. coli and/or K. pneumoniae acquisition status of neonates were assessed. Of 253 neonates admitted, 238 entered the active surveillance system. ESBL-producing K. pneumoniae was responsible for 7 infections and 51 colonizations while ESBL-producing E. coli was responsible for 9 infections and 88 colonizations. Concurrent isolation of both the organisms occurred in 30 neonates. The logistic regression model identified ‘length of stay in the NICU’ as the single independent risk factor. Imipenem, cefepime and amikacin can be suggested as the drugs of choice in our study.

Journal Article.  3367 words.  Illustrated.

Subjects: Paediatrics

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