Journal Article

Evaluating a Simple Method of Neuroprotective Hypothermia for Newborn Infants

A.R. Horn, M.C. Harrison and L.L. Linley

in Journal of Tropical Pediatrics

Volume 56, issue 3, pages 172-177
Published in print June 2010 | ISSN: 0142-6338
Published online September 2009 | e-ISSN: 1465-3664 | DOI:
Evaluating a Simple Method of Neuroprotective Hypothermia for Newborn Infants

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This study describes and evaluates a simple method of neuroprotective hypothermia for infants with hypoxic-ischaemic encephalopathy (HIE). Five term infants with HIE were cooled by applying soft, cold gel bags to the head. A radiant warmer, set to 34°C, servo-controlled the temperature measured at a probe between the infant’s back and the mattress. The infants’ heads were shielded from the warmer. After 72 h, the infants were re-warmed by 0.2°C per hour, by adjusting the radiant warmer. A rectal temperature of 34°C was attained in a median time of 45 min. Mean rectal temperatures during cooling were 33.9 ± 0.3°C. There was good correlation between insulated back temperatures and deep rectal temperatures (r = 0.76). There were no major or irreversible adverse events during cooling. This method of cooling achieved rectal temperatures within the target range of 33–34°C and re-warming was effective.

Keywords: newborn infant; therapeutic hypothermia; hypoxia-ischaemia; developing countries

Journal Article.  2698 words.  Illustrated.

Subjects: Paediatrics

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