Journal Article

Prevalence of Proteinuria Among HIV-infected Children Attending a Tertiary Hospital in Lagos, Nigeria

Christopher I. Esezobor, Edna Iroha, Elizabeth Onifade, Adebola O. Akinsulie, Edamisan O. Temiye and Chinyere Ezeaka

in Journal of Tropical Pediatrics

Volume 56, issue 3, pages 187-190
Published in print June 2010 | ISSN: 0142-6338
Published online September 2009 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmp090
Prevalence of Proteinuria Among HIV-infected Children Attending a Tertiary Hospital in Lagos, Nigeria

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Sub-Saharan Africa is the epicentre of the HIV pandemic but there are few reports of HIV-related kidney diseases in children in this region. This study aimed to determine the prevalence of proteinuria in HIV-infected children at the Lagos University Teaching Hospital. Proteinuria was determined using urine protein–creatinine ratio. CD4+ cell count was determined for all the HIV-infected children. The mean age of the HIV-infected children was 74.4 ± 35.6 months with a male: female ratio of 3:2. Compared with 6% of the 50 controls 20.5% of the 88 HIV-infected children had proteinuria (p = 0.026). Of 20 children with advanced clinical stage 40% had proteinuria compared with 14.7% of 68 children with milder stage (p = 0.004). Similarly, proteinuria was commoner among those with severe immunosuppression (p = 0.014). HAART use was not associated with significant difference in proteinuria prevalence (p = 0.491). Proteinuria was frequent among HIV-infected children, especially among those with advanced disease.

Journal Article.  2055 words. 

Subjects: Paediatrics

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