Journal Article

Increased Umbilical Cord Plasma Interleukin-1β Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

Jing Liu and Zhi-Chun Feng

in Journal of Tropical Pediatrics

Volume 56, issue 3, pages 178-182
Published in print June 2010 | ISSN: 0142-6338
Published online October 2009 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmp098
Increased Umbilical Cord Plasma Interleukin-1β Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

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To explore whether or not the umbilical blood levels of cytokines can be used to indicate the adverse outcomes of hypoxic-ischemic encephalopathy (HIE) patients. Umbilical artery blood and peripheral venous blood samples were collected on the 1st, 3rd and 7th days after birth to detect the levels of IL-1β, IL-8 and TNF-α. Neurological examination and Denver developmental screening test (DDST-II) were performed at the 6 and 12 months evaluations to detect any neurodevelopmental abnormalities. The results showed: (i) the serum concentrations of IL-1β, IL-8 and TNF-α in umbilical and peripheral blood were significantly higher in HIE patients than control groups; (ii) the umbilical blood concentrations of IL-1β exhibited the best positive correlation with HIE grades, when compared with IL-8 and TNF-α; and (iii) abnormal neurological outcomes at 6 and 12 months of age were best predicted by umbilical levels of IL-1β. Thus, umbilical concentrations of IL-1β were associated with the grades and adverse outcomes of HIE.

Journal Article.  2126 words. 

Subjects: Paediatrics

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