Journal Article

Haplotype of IL-8 -251T and 781C is associated with the Susceptibility to Respiratory Syncytial Virus

Aizhen Lu, Libo Wang and Xiaobo Zhang

in Journal of Tropical Pediatrics

Volume 56, issue 4, pages 242-246
Published in print August 2010 | ISSN: 0142-6338
Published online November 2009 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmp101
Haplotype of IL-8 -251T and 781C is associated with the Susceptibility to Respiratory Syncytial Virus

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Objective: To study the association of haplotypes of IL-8 -251T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV).

Methods: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele’s frequencies of SNPs were analyzed with case–control study, linkage of two loci and haplotypes composed by the two loci were also studied.

Results: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01).

Conclusion: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.

Keywords: respiratory syncytial virus; association study; single nucleotide polymorphism; IL-8; allele-specific polymerase chain reaction

Journal Article.  1498 words.  Illustrated.

Subjects: Paediatrics

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