Journal Article

Neurodevelopmental Outcome of Acute Bilirubin Encephalopathy

Kanya Mukhopadhyay, Gurdev Chowdhary, Paramjeet Singh, Praveen Kumar and Anil Narang

in Journal of Tropical Pediatrics

Volume 56, issue 5, pages 333-336
Published in print October 2010 | ISSN: 0142-6338
Published online February 2010 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmp142
Neurodevelopmental Outcome of Acute Bilirubin Encephalopathy

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The aim of the study was to determine the neurodevelopmental outcome of acute bilirubin encephalopathy (ABE) in children who underwent double volume exchange transfusion (DVET). The 25 referred newborns of ≥35 weeks gestation with total serum bilirubin >20 mg dl−1 and signs of ABE were enrolled and followed up at 3, 6, 9 and 12 months. Denver Development Screening Test (DDST), Neurological examination along with MRI at discharge and brain stem evoked response audiometry (BERA) at 3 months were done. Abnormal neurodevelopment was defined as either (i) cerebral palsy or (ii) abnormal DDST or (iii) abnormal BERA. The mean bilirubin at admission was 37 mg dl−1. MRI and BERA were abnormal in 61% and 76%. At 1 year, DDST and neurological abnormality were seen in 60% and 27% and 80% had combined abnormal neurodevelopment. MRI had no relation (P = 0.183) but abnormal BERA had a significant association (P = 0.004) with abnormal outcome. Intermediate and advanced stages of ABE associated with significant adverse outcome in spite of DVET.

Keywords: acute bilirubin encephalopathy; neurodevelopmental outcome; exchange transfusion; DDST; MRI; BERA

Journal Article.  1601 words.  Illustrated.

Subjects: Paediatrics

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