Journal Article

Short-course High-dose Dexamethasone Therapy for Chronic Idiopathic Thrombocytopenic Purpura in Children

Dinesh Yadav, Jagdish Chandra, Sunita Sharma and Varinder Singh

in Journal of Tropical Pediatrics

Volume 56, issue 6, pages 446-447
Published in print December 2010 | ISSN: 0142-6338
Published online April 2010 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmq022
Short-course High-dose Dexamethasone Therapy for Chronic Idiopathic Thrombocytopenic Purpura in Children

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First-line therapies of acute and chronic idiopathic thrombocytopenic purpura (ITP) include intravenous immunoglobulin, IV anti-D and corticosteroids. A short-course high-dose dexamethasone (HDD-SC) therapy has recently been reported to be efficacious in acute ITP. The present study was conducted to assess the efficacy of HDD-SC in children with chronic ITP. Over a period of 10 months, 13 patients with chronic ITP were given HDD-SC (20 mg m−2 IV daily for 4 days, four cycles repeated every 15 days). Of the 12 patients who could be evaluated, complete response was observed in 8 (66.6%) and moderate response in 2 (17%) patients, whereas 2 (17%) patients had no response. HDD-SC appears to be a safe and effective therapy in childhood ITP.

Keywords: ITP; dexamethasone

Journal Article.  1064 words. 

Subjects: Paediatrics

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