Journal Article

When to Screen Children with Down Syndrome for Celiac Disease?

Momcilo Pavlovic, Nedeljko Radlovic, Zoran Lekovic, Zorica Stojsic, Katja Puleva and Karolina Berenji

in Journal of Tropical Pediatrics

Volume 56, issue 6, pages 443-445
Published in print December 2010 | ISSN: 0142-6338
Published online April 2010 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmq026
When to Screen Children with Down Syndrome for Celiac Disease?

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The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.

Keywords: celiac disease; Down syndrome; tissue transglutaminase

Journal Article.  892 words.  Illustrated.

Subjects: Paediatrics

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