Journal Article

Celiac Disease in Children and Adolescents with Autoimmune Hepatitis: a Single-centre Experience

Mortada El-Shabrawi, Hanaa El-Karaksy, Nabil Mohsen, Mona Isa, Mohammed Al-Biltagi and Mervat El-Ansari

in Journal of Tropical Pediatrics

Volume 57, issue 2, pages 104-108
Published in print April 2011 | ISSN: 0142-6338
Published online June 2010 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmq057
Celiac Disease in Children and Adolescents with Autoimmune Hepatitis: a Single-centre Experience

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Objectives: Celiac disease (CD) is increasingly reported from North Africa, including Egypt. Autoimmune hepatitis (AIH) is considered a high risk factor for CD. We aimed to investigate the frequency of CD diagnosis in AIH.

Methods: We prospectively enrolled 26 AIH patients aged 3.5–21 (mean 9.98 ± 3.94) years and 20 healthy age- and sex-matched controls. Serodiagnosis of CD was based on the most sensitive tests namely immunoglobulin A (IgA) human tissue transglutaminase antibody (IgA-tTGA) by enzyme-linked immunosorbent assay and/or IgA endomysial antibody (IgA-EMA) by immunofluoresence and confirmed the diagnosis by upper gastrointestinal endoscopy and histo-pathological findings in jejunal biopsy.

Results: IgA-EMA was positive in four patients (15.4%), whereas IgA-tTGA was positive in two of them (7.7%). Histopathology was confirmatory in three (11.5%) seropositive patients.

Conclusion: The high prevalence (11.5%) of CD among Egyptian children with AIH indicates that CD exists in high-risk groups in our region and must be carefully looked into.

Keywords: Celiac disease; autoimmune hepatitis; Egypt; North Africa

Journal Article.  2140 words. 

Subjects: Paediatrics

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