Journal Article

Weekly Iron Supplementation for the Prevention of Anemia in Pre-school Children: A Randomized, Double-blind, Placebo-controlled Trial

Francisco Plácido Nogueira Arcanjo, Cecília Costa Arcanjo, Olga Maria Silverio Amancio, Josefina Aparecida Pellegrini Braga and Álvaro Jorge Madeiro Leite

in Journal of Tropical Pediatrics

Volume 57, issue 6, pages 433-438
Published in print December 2011 | ISSN: 0142-6338
Published online February 2011 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmq119
Weekly Iron Supplementation for the Prevention of Anemia in Pre-school Children: A Randomized, Double-blind, Placebo-controlled Trial

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Objective: This study analyses the impact of weekly iron supplementation with ferrous sulphate heptahydrate (FeSO4) in 5-year-olds compared with placebo, on hemoglobin (Hb) and hematocrit (Ht) values and anemia. Design: The study concerns a cluster-randomized, placebo-controlled double-blind trial. Intervention participants received 50 mg elemental iron for 14 weeks. Setting: The study population comprised pre-school children (n = 135) from one randomly chosen public school in the northeast of Brazil. Subjects: Participants were 5-year-old students from a public school. Results: Mean Hb and Ht values increased after iron supplementation, with p < 0.0001. There was no statistically significant increase in the placebo group. After intervention, anemia prevalence reduced only in the intervention group, from 48.0% to 26.0%. Conclusions: Weekly iron supplementation was effective in reducing anemia in 5-year-olds.

Keywords: iron; supplementation; pre-school children; hemoglobins; anemia

Journal Article.  2766 words.  Illustrated.

Subjects: Paediatrics

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