Journal Article

Long-term Consequences of the Early Treatment of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Nanjing, China: a 12-year Follow-up Study

Qing Sun, Yu-Lin Chen, Zhang-Bin Yu, Shu-Ping Han, Xiao-Yue Dong, Yu-Fang Qiu, Li Sha and Xi-Rong Guo

in Journal of Tropical Pediatrics

Volume 58, issue 1, pages 79-80
Published in print February 2012 | ISSN: 0142-6338
Published online February 2011 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmr010
Long-term Consequences of the Early Treatment of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Nanjing, China: a 12-year Follow-up Study

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This study was performed to investigate the prevalence of congenital hypothyroidism (CH) in neonates in Nanjing, China and the long-term consequences of early treatment. A total of 442 454 neonates were screened for CH and 183 neonates were confirmed, with a prevalence of 1 in 2418. Of these, 163 neonates completed the follow-up process and 163 healthy children were recruited as the control group. The height, weight and body mass index (BMI) of the children with CH from 0.5 to 6 years were not significantly different from the control group (p > 0.05). The children with CH had a significantly increased risk for being overweight or obese between 0.5 and 6 years (p < 0.05). The children with CH showed a significantly lower developmental quotient (DQ) than the control group in all four areas of the Gesell test (p < 0.05). The results suggest that children with CH that has been identified by newborn screening and early treatment have normal growth and neuromotor development.

Keywords: congenital hypothyroidism; neonatal screening; growth; developmental delay; obesity

Journal Article.  785 words. 

Subjects: Paediatrics

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