Journal Article

Efficacy of Dioctahedral Smectite in Acute Watery Diarrhea in Indian Children: A Randomized Clinical Trial

Quais Mohammad Mujawar, Ravi Naganoor, Mir Dilshad Ali, Naushad Malagi and Achyut Narayan Thobbi

in Journal of Tropical Pediatrics

Volume 58, issue 1, pages 63-67
Published in print February 2012 | ISSN: 0142-6338
Published online April 2011 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmr030
Efficacy of Dioctahedral Smectite in Acute Watery Diarrhea in Indian Children: A Randomized Clinical Trial

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Objective: To determine the effects and safety of dioctahedral smectite (DS) on the duration of acute watery diarrhea in children. Methods: A Randomized, open labeled, clinical controlled trial in a tertiary care hospital outpatient department (OPD) and emergency department. Participants were one hundred and seventeen children without any chronic illness between 2 and 5 years presenting to OPD, having acute watery diarrhea for <48 h with mild to moderate dehydration, not on antibiotics and requiring oral rehydration therapy. Intervention done was DS with a dose of 1.5 g thrice daily. Results: Freshly dissolved DS in a dose of 1.5 g thrice daily for 5 days significantly shortened the duration of acute watery diarrhea in children aged 2–5 years. There were no adverse effects on the use of DS. DS was acceptable to the children, and its administration was not accompanied with any side effects. Conclusion: DS reduces the duration of diarrhea in Indian children and prevents a prolonged course, and therefore, may consistently reduce the costs in treatment of acute watery diarrhea.

Keywords: diarrhea; dioctahedral smectite; dehydration

Journal Article.  2030 words.  Illustrated.

Subjects: Paediatrics

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