Journal Article

Effect of Zinc Supplementation on Growth in Very Low Birth Weight Infants

T. V. Ram Kumar and Siddarth Ramji

in Journal of Tropical Pediatrics

Volume 58, issue 1, pages 50-54
Published in print February 2012 | ISSN: 0142-6338
Published online May 2011 | e-ISSN: 1465-3664 | DOI:
Effect of Zinc Supplementation on Growth in Very Low Birth Weight Infants

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This was a randomized blinded placebo controlled trial undertaken to study the role of zinc supplementation on growth, primarily the linear growth velocity in very low birth weight (VLBW) infants at 3 months corrected age (CA). Out of 134 neonates with birth weight <1500 g, 101 babies were eligible. Due to lack of consent 10 were excluded. The remaining 91 neonates who were comparable for sex, gestational age, birth weight, APGAR and age at enrollment were randomized to receive either 1 ml of zinc sulfate (10 mg elemental zinc) (n = 46) or 1 ml placebo (n = 45) from enrollment to 60 days. The infants in the zinc group had significantly higher linear growth velocity (0.98 ± 0.12 cm week−1) compared to a placebo group (0.67 ± 0.15 cm week−1) (p < 0.001) at 3 months CA. We concluded that zinc supplementation at 10 mg day−1 for 60 days in VLBW infants improves their linear growth during infancy.

Keywords: Low birth weight; zinc; growth

Journal Article.  1996 words.  Illustrated.

Subjects: Paediatrics

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