Journal Article

Evolution of lipid levels in HIV-infected children treated or not with HAART in Abidjan, Côte d’Ivoire

Amandine Cournil, Sabine Mercier-Deheuvels, Anne-Marie Dupuy, Jean-Paul Cristol, Marie-France Anaky, François Rouet, Patricia Fassinou and Philippe Msellati

in Journal of Tropical Pediatrics

Volume 58, issue 1, pages 43-49
Published in print February 2012 | ISSN: 0142-6338
Published online May 2011 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmr038
Evolution of lipid levels in HIV-infected children treated or not with HAART in Abidjan, Côte d’Ivoire

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Objective: To describe lipid levels in antiretroviral (ARV)-naïve HIV-infected Ivorian children and assess their evolution after ARV-treatment initiation. Methods: Lipid concentrations were assessed at baseline and at least 6 months later in 93 children. Fifty-six children initiated ARV treatment at baseline, and 37 remained untreated. Results: At baseline, 65, 92 and 84% of the children had low levels of total cholesterol, HDL and APOA1, respectively, whereas 75 and 70% had triglycerides and APOB levels in the normal range. At baseline, low level of HDL cholesterol and high level of triglycerides were associated with high viral load and low levels of CD4 cell count. Levels of total, HDL cholesterol and APOA1 increased over time, and treatment was associated with a higher increase whereas levels of triglycerides and APOB decreased in treated children and remained stable in untreated group. Conclusions: The initiation of antiretroviral treatment was associated with a normalization of the infection-related lipid profile.

Keywords: HIV; children; Africa; lipid metabolism; dyslipidemia; antiretroviral treatment

Journal Article.  2914 words.  Illustrated.

Subjects: Paediatrics

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