Journal Article

A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

Akintunde Sowunmi, Ibukun A. Akinrinola, Grace O. Gbotosho, Titilope M. Okuboyejo and Christian T. Happi

in Journal of Tropical Pediatrics

Volume 58, issue 4, pages 263-268
Published in print August 2012 | ISSN: 0142-6338
Published online November 2011 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fmr091
A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

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A dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children. Children on DRAAAS received 0.8–1.0 of artesunate/kg and 0.9–1.2 times amodiaquine/kg compared with those receiving SDRAA. Parasite and fever clearance and fall in hematocrit in the first 3 days were similar; both regimens were well tolerated. DRAAAS is simple and is efficacious.

Keywords: dose regimen; arm span; anti-malarials; children

Journal Article.  1643 words.  Illustrated.

Subjects: Paediatrics

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